Employing (Home) Organisation: Nnamdi Azikiwe University Awka
Project title: Targeting G-Quadruplex DNA in Trypanosoma brucei with Photoactivated Ruthenium(II) Polypyridyl Complexes for Human African Trypanosomiasis Therapy
I am a researcher trained in chemical and structural biology, currently working in academia with research interests in antimicrobial resistance, neglected tropical diseases, and cancer-related research. Although I have always been inclined toward research, my transition to health-focused research was shaped by my mother’s illness, which profoundly influenced my career path. My current research direction has been guided by Prof. Christine and Prof. Ikenna Onyido, my PhD supervisor, whose mentorship motivated my application for the AREF Award.
Summary of Project Destination
Human African trypanosomiasis (HAT) remains a neglected tropical disease with limited, toxic treatment options and emerging drug resistance. This project asks whether photoactivated ruthenium(II) polypyridyl complexes targeting G-quadruplex DNA can disrupt telomere maintenance and antigenic variation in Trypanosoma brucei, enabling selective antitrypanosomal activity. Through structural, biochemical, and photochemical approaches, the fellowship will support optimisation of G-quadruplex binding and mechanistic validation of parasite-specific targeting. After the fellowship, I will transfer these techniques to my home institution, establish G-quadruplex screening platforms, mentor early-career researchers, and develop follow-on funding proposals. The project aims to deliver a novel, light-activated therapeutic strategy for HAT while strengthening local research capacity in Africa.
Summary of Fellowship Plan
I will be placed at the University of Reading under Prof. Christine, whose internationally recognised expertise in G-quadruplex biology and structural nucleic acid research directly supports my project on T. brucei. The placement will provide advanced training in G-quadruplex targeting, structural analysis, and translational drug discovery using facilities unavailable at my home institution. On return, my EO Academic Sponsor, Prof. Uche E. Ekpunobi, will support reintegration through mentoring, access to resources, skills dissemination, and alignment with departmental research priorities to sustain and advance the project.
Quote
“If we aim to heal all, innovative approaches to neglected diseases must be grounded in rigorous, collaborative science, says Dr Emmanuel C. Ohaekenyem“
Proposed start date of the Fellowship is August 2026